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Nature Immunology volume 25, pages 399–400 (2024 )Cite this article nettle root extract
Cancer cells often rely on glycolysis for energy metabolism. Increased glycolysis leads to the increased production of lactate and H+ ions, which should hypothetically lower intracellular pH. However, we find that tumor cells combat intracellular over-acidification by synthesizing carnosine, especially under hypoxic conditions, which allows them to control lysosome-dependent galectin-9 expression and evade T cell-mediated immune surveillance.
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This is a summary of: Yan, R. et al. Carnosine regulation of intracellular pH homeostasis promotes lysosome-dependent tumor immunoevasion. Nature https://doi.org/10.1038/s41590-023-01719-3 (2024).
Carnosine helps cancer cells to evade immune surveillance by regulating intracellular pH. Nat Immunol 25, 399–400 (2024). https://doi.org/10.1038/s41590-023-01740-6
DOI: https://doi.org/10.1038/s41590-023-01740-6
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Nature Immunology (Nat Immunol) ISSN 1529-2916 (online) ISSN 1529-2908 (print)
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