Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.
Nature Chemical Engineering volume 1, pages 327–329 (2024 )Cite this article N-Methyl-L-Alanine Powder
![A changing paradigm in industrial pharmaceutical crystallization | Nature Chemical Engineering](http://cdn.globalso.com/bsxaminoacids/structured-68.jpg)
Crystallization plays a pivotal role in the manufacturing of pharmaceuticals. This Comment briefly reflects on past achievements and emerging opportunities in industrial crystallization, particularly considering increasing molecular and system complexities.
This is a preview of subscription content, access via your institution
Receive 12 digital issues and online access to articles
Prices may be subject to local taxes which are calculated during checkout
Cote, A. et al. Cryst. Growth Des. 20, 7568–7581 (2020).
Analysis Group for PhRMA Innovation in the Biopharmaceutical Pipeline (Pharmaceutical Research and Manufacturers of America, 2021).
dos Santos, R., Carvalho, AL & Roque, ACA Biotechnol.Adv. 35, 41–50 (2017).
Puhl, S., Meinel, L. & Germershaus, O. Asian J. Pharm. Sci. 11, 469–477 (2016).
Verma, V., Bade, I., Karde, V. & Heng, J.Y. Pharmaceutics 15, 1288 (2023).
Article CAS PubMed PubMed Central Google Scholar
Chen, W. et al. Cryst. Growth Des. 20, 866–873 (2020).
Li, X. & Heng, JYY Chem. Eng. Res. Des. 173, 81–88 (2021).
Li, X. & Heng, J. Y. Y. CrystEngComm 23, 8386–8391 (2021).
Capellades, G., Bonsu, J. O. & Myerson, A. S. CrystEngComm 24, 1989–2001 (2022).
Nordstrom, F. L. et al. Org. Process Res. Dev. 27, 723–741 (2023).
Simon, L. L. et al. Org. Process Res. Dev. 19, 3–62 (2015).
Xiouras, C. et al. Chem. Rev. 122, 13006–13042 (2022).
Article CAS PubMed Google Scholar
Lovette, M. A. et al. Cryst. Growth Des. 22, 5239–5263 (2022).
Landis, S., Zhao, Y. & Doherty, M. F. Comput. Chem. Eng. 133, 106637 (2020).
Richard, A. M. Chem. Res. Toxicol. 19, 1257–1262 (2006).
Article CAS PubMed Google Scholar
Gilead Sciences Inc., Foster City, CA, USA
Eli Lilly and Company, Indianapolis, IN, USA
Boehringer Ingelheim, Ridgefield, CT, USA
You can also search for this author in PubMed Google Scholar
You can also search for this author in PubMed Google Scholar
You can also search for this author in PubMed Google Scholar
You can also search for this author in PubMed Google Scholar
Correspondence to Stefani Kocevska, Christopher L. Burcham, Fredrik Nordstrom or Giovanni Maria Maggioni.
The authors declare no competing interests.
Kocevska, S., Burcham, C.L., Nordstrom, F. et al. A changing paradigm in industrial pharmaceutical crystallization. Nat Chem Eng 1, 327–329 (2024). https://doi.org/10.1038/s44286-024-00068-8
DOI: https://doi.org/10.1038/s44286-024-00068-8
Anyone you share the following link with will be able to read this content:
Sorry, a shareable link is not currently available for this article.
Provided by the Springer Nature SharedIt content-sharing initiative
Nature Chemical Engineering (Nat Chem Eng) ISSN 2948-1198 (online)
![A changing paradigm in industrial pharmaceutical crystallization | Nature Chemical Engineering](http://cdn.globalso.com/bsxaminoacids/product-637.jpg)
N-Acetyl-L-Tyrosine Powder Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.