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Nature Immunology volume 25, pages 399–400 (2024 )Cite this article hyaluronic
![Carnosine helps cancer cells to evade immune surveillance by regulating intracellular pH | Nature Immunology](http://cdn.globalso.com/demeterherb/Noni-powder-6.jpg)
Cancer cells often rely on glycolysis for energy metabolism. Increased glycolysis leads to the increased production of lactate and H+ ions, which should hypothetically lower intracellular pH. However, we find that tumor cells combat intracellular over-acidification by synthesizing carnosine, especially under hypoxic conditions, which allows them to control lysosome-dependent galectin-9 expression and evade T cell-mediated immune surveillance.
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This is a summary of: Yan, R. et al. Carnosine regulation of intracellular pH homeostasis promotes lysosome-dependent tumor immunoevasion. Nature https://doi.org/10.1038/s41590-023-01719-3 (2024).
Carnosine helps cancer cells to evade immune surveillance by regulating intracellular pH. Nat Immunol 25, 399–400 (2024). https://doi.org/10.1038/s41590-023-01740-6
DOI: https://doi.org/10.1038/s41590-023-01740-6
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Nature Immunology (Nat Immunol) ISSN 1529-2916 (online) ISSN 1529-2908 (print)
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